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a scientific advances in neuroscience immunology and dermatitis psoriasis and scabies are examples of pruritic diseases that are not primarily due to histamine. by definition ad their action is multisystemic and does not represent targeted therapy. possible side effects include decreased bone density
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13. weinberg jm lebwohl m. advances in psoriasis a multisystemic guide. springer london heidelberg new york dordrecht 2014 301 315. 14. ryan c korman nj gelfand jm. research gaps in psoriasis opportunities for future studies. j am acad dermatol 2014 70 146 67. 15. christophers e. psoriasis epidemiology and clinical spectrum.